Efficacy and Safety of Viagra (Sildenafil Citrate)

Efficacy and Preventive of Viagra® (Sildenafil Citrate) in Men With Cardiovascular Disease and Erectile Dysfunction  CME

Aspect

Erectile dysfunction (ED) is a unwellness with a high generality in patients with cardiovascular disease (CVD) due to several factors.
The same risk factors (diabetes, vaporization, and hypertension) are implicated in the pathogenesis of both diseases.
In gain, certain drugs used in the management of CVD may induce ED ( eg, thiazide diuretics, digoxin, and beta blockers).

Aim

The aim of this subject area, which was presented at the Scientific Sessions of the 49th American English Building complex of Cardiology association was the sorting of the efficacy and prophylactic of viagra for the discourse of ED in patients with CVD.

Methods

A sum of 224 men with ED and CVD, who were not under nitrate therapy, were randomized to either viagra (n=136) or vesper (n=88) in this 12-week, double-blind study; 83% of the men had hypertension, 19% had previous myocardial infarction; 17% had coronary arteria disease, 17% had inflammatory disease, 14% had previous coronary ringway, 12% had peripheral vascular disease, and 5% had congestive cognitive content omission.

The dose of viagra was started at 50 mg, which could be adjusted to 100 mg or 25 mg based on efficacy and tolerability.
The therapy was taken approximately 1 hour before sexual human action, not more than once daily, 10 meter reading per calendar month on scale value.

The efficacy of the direction was assessed using Proposal of marriage 3 (Q3; knowledge to achieve erections) and Query 4 (Q4; noesis to maintain erections) of the International Indicator of Erectile Software (IIEF).
The answers were then graded on a leafage of 1 (almost never/never) to 5 (almost always/always).

Results

viagra attention significantly improved erectile utility in men with CVD and ED.
The mean incision for Proposal 3 (ability to achieve erections) increased from 1.8 +/- 0.14 at standard to 3.9 +/- 0.16 (P < .0001) in week 12 in patients receiving viagra in similitude to a cash of 2.2 +/- 0.19 to 2.4 +/- 0.19 in the medicine chemical group.
Accordingly, the mean seduction for Query 4 (ability to maintain erections) increased from 1.5 +/- 0.12 at service line to 3.5 +/- 0.18 (P < .0001) in week 12 in patients receiving viagra in comparability to a outcome of 1.6 +/- 0.14 to 2.1 +/- 0.21 in the medicament chemical group.
The figure of patients reporting an change of state of their erections was significantly higher in the sildenafil building block (71% vs 24% in the medicament group).

The most common adverse events were flushing (17% of viagra, 2% placebo), concern (15% viagra, 1% placebo), and dyspepsia (4% viagra, 0% placebo), with nearly all of these beingness mild or moderate.
Ten patients (7%) in the sildenafil abstraction and 8 patients (9%) in the medicament grouping discontinued treatment; only 1 case discontinued because of an adverse issue (placebo group), the others because of lack of efficacy.
Four patients (3%) in the viagra set and 2 patients (2%) in the medicinal drug chemical group had serious adverse events, but none were considered by the investigators to be care related.

Finis

The authors conclude that oral sildenafil is an effective and well-tolerated discourse for ED in patients with CVD who are not taking nitrate therapy.

Patients in the sildenafil discussion abstract entity had significant increases in their abilities to achieve and to maintain erections.
The adverse events were mild to moderate in type, and besides flushing, no adverse events were deemed to be care related.

Scuttlebutt

This room has shown that sildenafil is well tolerated in patients with cardiovascular disease who are not taking nitrate therapy and is thus in concord with previous studies.
Nevertheless, it has to be used with discretion, particularly in certain patient role groups that have not been sufficiently studied, such as patients with unstable cardiopathy, congestive inwardness fate, motion, or uncontrolled hypertension, or in patients after an acute myocardial infarction, among others.
This is a part of article Efficacy and Safety of Viagra (Sildenafil Citrate) Taken from "Levitra Vs Sildenafil" Information Blog